I will be in Philadelphia for a couple weeks on business and plan to hit some of the local casinos (Harrah's and Parx are the closest casinos to where I'll be that spread LHE), and maybe even make the trip out to Atlantic City if I get off work early enough (would love to play at the Borgata just to say I did). Several casinos in the area have 2-4-6 LHE, which from what I understand is a $1 sb, a $2 bb, bets pre and on the flop are increments of $2, on the turn $4 and on the river $6.

First things first, I understand that making the river $6 increments does very little to help beat the rake, and I can live with that - I'm not a serious player.
Some of the local casinos offer higher, like 4/8. 5/10 would be the highest I could realistically play (I'm very bankroll challenged).

OK enough of the personal biography nonsense - on to the question!

It seems like the only adjustment one would need to make in such a game is to adjust calculations for implied odds and (perhaps more importantly) reverse implied odds. You need slightly less odds to call with that turned gutshot to the nuts when you're sure the villain will call a river bet when the river bet is $6 than when it's $4. My brain isn't working right now so I can't think of an example of when it would affect RIO.

You still want to build big pots with premium hands before the flop, you still want to raise the flop either when you have an equity advantage or to get a free card, you still want to pay attention to the probability of your pot equity changing significantly from street to street etc.

Any adjustments to a game like 2-4-6 that I'm overlooking?

The cheeky answer is that I'd play up to the turn like I'm playing 2/4 and the river like I'm playing 3/6 and because I'd play 2/4 and 3/6 the same way it doesn't matter, hurr hurr hurr.

I mean it changes your implied odds but it's really hard to predict by how much because peoples' behaviors change so much (as exemplified in kill pots where loose players suddenly clam up or tight players suddenly lose their minds).

I played the 2-6 spread at the Excalibur years ago, good times.

You raise KJo in mp and get four way action. The board runs out KdTh7c 6h 8h. You got three calls on the flop and two on the turn. You're oop.

Would you play this hand any differently if it were 2-4 vs. if it were 2-4-6? Raising pre and betting the flop and turn are trivial IMHO. The worse hands that are calling outnumber the better hands that are calling by a very wide margin. The river rams a bleep right up our bleeps.

Assuming for simplification that both blinds called pre, that's 8 sb pre, 4sb on the flop and 6 sb on the turn, total 18x2=$36.

I'm not betting that river in 2-4 *or* 2-4-6. In 2-4 if one of the villains does bet we're getting 10 to 1 on a call. In 2-4-6 if one of the villains bets we're getting 7 to 1 on a call. In both cases we may or may not be closing the action. At passive tables nobody's betting there as a bluff - I have to have seen the villain pull that off before I believe he'll do it.

If I'm closing the action at a 2-4 table I think I call, but I think it's a mistake to call (I'm just not good enough to fold there). At a 2-4-6 table I'm not sure I put any more money in that pot. EDIT: As a matter of fact, to callypgian's point, the higher price to bet makes it even less likely that it's a bluff, so I'm 99% sure I don't put another chip in the pot with TP3K.