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I'm interested in putting together the hardware needed to effectively run PioSolver Edge and perform preflop calculations
Make sure to read my posts about hardware in this thread. Look at last 100-200 posts and ctrl+f cpu/hardware/intel/server
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My current rough plan is to build a desktop PC using 2 Xeon E5-2670 processors, each 8 core with 2.6Ghz.
Those are quite decent CPUs.
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I wanted to get a sense of the speed possible for the max calculations
Again, read my posts in this thread. 16 x 2.6 = 41.6 as it's sandy bridge you need to deduct some also having 16 cores is worse (for scaling) than having less a bit so my hardware score would be about 39.
In comparison non overclocked i7 5820k gets 19.8. This means that Xeon setup will be less than 2x faster than i7 5820k.
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estimate the time it would take to produce a strategy for 100BB effective stack with 2 bet and raise sizes (and AI first/last) on all streets including preflop using this setup?
Short answer: it's completely unrealistic tree and it's not even close to being realistic.
Long answer: assuming you go easy on sizes in 3 and 4 bet pots you would need about 5TB of RAM and it would take about 2 months to solve (assuming 72 flop subset)
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if there is a superior setup I could put together for less than 10k that would result in significant speed gains over my existing plan
I don't have any more hardware advice than I already provided in this thread. It's better to ask people who are experts at assembling hardware or find some local hobbyist to help you with that.
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it possible to perform a GTO calculation from preflop with say 10 flops and then to manually go through each flop editing/locking a range (e.g. one villain's flop Cbet range) and run the calculation again from preflop and have the program respect the postflop locks? I want to see the impact of a player deviating from GTO postflop on preflop play.
To be honest I haven't tested postflop locking on preflop trees but it should work.
The reason I haven't tested it is that it's unrealistic to do. You would need to lock many flops an then solve gain - it take a very long time to do both. I definitely wouldn't recommend it.