For an advanced player both sets should be clearable in a few different ways so the problem is somewhat irrelevant in that case. If you aren't a good enough player to be clearing regularly from here then it really depends on the rule set used, but assuming it's an English table and English pub rules or world rules (2 visits for a foul) I think yellows are a mistake because you miss a shot and you either lose or you're in deep trouble.
As Wamy said in the OP, "weak players in such a situation will often pot every easy red and then seem confused when they miss their hard/blocked balls and go on to lose, questioning why they keep losing such frames when they appeared so close winning"
I think yellows are exactly like that. There are a lot of yellows available to pot, but all it takes is one wrong positional shot and you're in a bit of trouble. With reds there are a lot of safety shots available at all points, and missing a pot will generally leave the pocket blocked for a yellow.
Using baptz' diagram:
A typical amateur visit for yellow would be to roll the yellow in the middle, pot the yellow in the bottom right and have the frame go downhill from there getting further and further out of position. Or, if they go for reds, it would usually be to pot something like 3, 1, 5, 4, then be totally out of position on everything else.
IMO the correct way to approach this if you aren't a confident player is to roll the 5 in, then cover the bottom left pocket with the 6 (rolling the white through a little to block yellow's pots). If it blocks the pocket then yellow won't clear and will have a pretty tough safety, and if it sinks then there's an out with the 3 or 4, followed by possibly rolling the 1 over the pocket. I can't see a weakish player clearing from this starting position regardless, so covering a pocket and tying the game up a little is a good way to go.
The other thing to point out is that most amateurs struggle with position, especially using spin on the white. The first shot on yellow is either the pot to bottom left, stunning the white between the 5 and 6, or the yellow to middle with deep screw (or right spin to take it round the two yellows). Both of those shots can EASILY go wrong. With reds, most shots can be hit plain ball and basically rolled in dead weight. The only tricky shot is trying to get onto the 7 into the right corner, but there are a few balls available to get across to there from.