you should be thinking in terms of "nuts".. and the river is the most important street vs these types of players as it has the biggest bets so thats where they make the biggest mistakes.
Example:
Q
9
7
A
6
nuts to 2PR.. are T8,85,AA,QQ,99,77,66,AQ,A9,A7,A6,Q9,Q7,Q6,97,96,76 .
thats 17 hands, vs a player that likes to call i would value bet this river with AQ+. these types of players like to put you on busted flushes or one pair type hands and call down with 2 pair. also if you get raised you can easily fold knowing that the passive, any 4 cards player very likely has you beat. obvioulsy if theyre aggro postflop than you have to adjust.
dont bluff them. take them straight to value town and print money. i dont even bet the dry Ace on a mono flop vs these types as they just dont give a S**T. i honestly think their mentality is "i came to play PLO and gamble, i have now flopped a flush, so im going to see if he also has flopped a bigger flush and i lose or i win" lol you cant "bluff" mentality.