Quote:
...Is it correct to assume they are opening 40% of all 1326 hands...
Yes.
Quote:
... is there any validity to weighting their range slightly...
You should do this everytime cuz players criteria on what is a top X%of hands varies but only at the middle-bottom section of those ranges, towards the top there´s seems to be some generic agreement (obv).
Quote:
...to account for card distribution considering that 6 players had 'unplayable' hands?...
This is something you should always considered too, its called "card removal effect".