I don't have my pc yet. but when I do I'll have 64gb of ram.
I'm planning on running scripts with:
Bet sizes: 29%,70%,130%
Donk sizes: 29%, 70%
Raise sizes: 3x,5x

My main questions are:
are my sizes good?
can I limit the number of donk sizes and raise sizes to just one size without a substantial EV loss?
If I do run this sim with multiple donk/raise sizes, is 64gb of ram enough?

I just got Pio and I have 16 gigs of RAM and trust me that 16 gigs of RAM already knows more about poker than I ever will.

The idea I've gotten from reading other threads is that for bet sizes you kind of just have to play around with it to see if your bet sizes matter. Take a couple hands you're real interested and run them with a half-dozen different options for bet sizes to see if EV changes at all.

Also 29% is oddly specific, especially since the pot has to be $100 before it even works out to a non-fractional bet.

29% is right in between 1/4 and 1/3 which are typical small bet sizes. Same for 70% etc. That's why I chose those sizes.

These are not simple questions lol. In my experience, choosing sizes is a learned skill that you get better at the more sims you look at. Over time you just realise that some sizes don't get used almost ever, and once in awhile you experiment with a ridiculously big or small size and discover that it does in fact get used in certain nodes.

Some random things I've learnt:
-Include a geometric (2e) raise size OOP on the turn, gets used more often than you think
-One smallish donk size is enough, it's pretty rare for OOP to donk big into an uncapped range
-Don't bother having a 29% river size in position, all the hands that are worth 29% should just be checking back.
-River raise sizes should be big for the same reason (I use 80%+allin)

As for flop sizes, I assume you're not planning to play 3 sizes on the flop, so I would do some work to figure out which is the best size and then just run sims with that size.

You can also use GTOWizard. You'll have solutions to all post flop scenarios with a lot of different sizing post flop(you cant run such sims on PC).
If you want to run your own sims, you can use GTOWizard to figure out what sizngs are used in specific spot. This will save you a lot of time and it's pretty cheap. Send me PM if you are interested.

Hah yes, that's probably more time-efficient.

That was very helpful. Thanks man!