Beware, If you make it through this post you will find something very very interesting about the human genome that most people do not know...
There is one last thing I want to talk about with regards to creating mutations in an organisms genome and that is viruses. Without a doubt, viruses have been a big player in creating genetic diversity in the living world.
(Background: a virus is not composed of 'cells' as other organisms are. They are primary made up of a protein shell called a "capsid", and inside this shell is its genetic material. Their genetic material can be DNA or it can be RNA instead. Viruses can only replicate inside of another organisms cells called a "host". For this reason, many people do not consider them living creatures. Many of them are very small, even much smaller than a bacterial cell)
Okay so I previously mentioned how viruses can facilitate gene transfer in microorganisms and other living beings. Well there are other types of viruses which can do something different. These viruses can take their entire genome and insert it into their host's genome. This is what happens with famous human viruses such as HIV and Herpes, and it is the reason why once you get them, you cannot ever get rid of them! Here is a video of HIV replication and how it integrates into your DNA (you can skip to ~2:45 if you don't want to watch the whole thing, but you should at least see how this virus inserts its genome into yours to understand what comes next in this post)
http://www.youtube.com/watch?v=RO8MP...eature=related
Once this virus does this, then when your DNA is expressed, the virus DNA also is, and new viruses form. They then leave your cell and infect other cells. But the viral DNA still remains in the host DNA!
Thus new genetic variability has been created.
Now how does this specific example I brought up relate to humans?
Turns out that ~8% of the human genome is composed of these viral DNA sequences that integrated into our ancestors DNA at various points in time, thousands, hundreds of thousands, and millions of years ago! (they are commonly called human endogenous retroviruses) They have been there for so long that these sequences do not actually produce viruses anymore since they have undergone enough mutations to keep them from actually functioning. Also, these sequences can jump to other regions in our DNA just like the other "jumping gene" example I mentioned in another post.
Even though many of these sequences no longer are expressed (some of these regions are what some people call "junk DNA"), parts of these viral sequences do get expressed and yield only parts of these viruses such as proteins, or enzymes.
Now comes the big question: Have humans been able to take these sequences and use the information that they encode (which has been mutated over time), for their benefit? YES! This is a very new topic in its infancy since genome sequencing is pretty new, but researchers have already found ways that these have been used. One new way found is that one of these sequences from these viruses have evolved to form a protein which helps certain cells stick to other cells during the formation of the placenta during pregnancy!