I would put Venetian in the premier tier, for the sheer depth and volume they have at 1/3 and 2/5.
Also probably the 2nd best place for PLO, behind Aria.
And their deepstack tournament series, if you're into that sort of thing.
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If I'm going to play 1/2 or 1/3, is there any discernable difference in game quality between these 3 categories of rooms? Like you might find more good players at a place like Aria or Wynn and drunken bad players at Planet Hollywood (before it closed). Or is it all YMMV and with so many games in town it's best to just table select until you find a good game?
There's no "best 1/2 game in town," every 1/2 game will have its own mix of regs, nits, and total donators. If you're at a 1/2 table anywhere in town and it doesn't have at least 2 or 3 soft spots, just rack up and find a new table, or even a new casino.
I tend to prefer the premier rooms just because they offer the most traffic and game selection in one place. There are definitely some solid regs that populate those games as well, too, though.