Quote:
Originally Posted by JohnnyFondue
So just a little break in between sets, even if just for a few minutes, causes a completely different change in adaptation than doing more reps per set?
This is hardly a beginner question, but to answer your question, I don't really think it matters if you take more time between sets. When I was doing volume (5x5) work, I started off with 3-5 minute breaks between the first few sets and upwards of 10 minutes for the last ones. Without them, there would have been no way I could have gotten all the reps.
Let's assume that it does make a significant difference. What's worse: Failing reps because you don't take long enough, or biasing your programming slightly towards hypertrophy rather than maximum strength?