I was on Accutane in high school. Absolutely 100% no regrets, although I think I may have had a mild bout of depression while on it (but ****, I was in high school, so it could've been just a weird mood swing.) The advice above about vaseline on the lips is good, but an even better product is Bag Balm
http://www.bagbalm.com. Its actually made for farmers to put on chapped cow udders, its the consistency of vaseline, but worked way better for me. My hands got so dry I would actually smear the bag balm on my hands before bed then wear white cotton gloves (to save my sheets) to help alleviate the dryness. I would also get about 1 nosebleed every two weeks (to help this, I would dip a Q-tip in vaseline then smear it in my nostrils.) I responded so well that my dermatologist stopped my treatment a month early.