Please tell me that I'm not the only one who starts a run with a killer item from the first level, and then proceeds to find every single possible negative pill on level 2.
Or it'll be one of those games where I manage to get 12 red hearts, but zero damage upgrades and I just die slowly and painfully on the womb.
Or I'm playing an amazing glass cannon build (brimstone or similar) and I run into a room with lots of negative space on the outer rim, and a platform in the middle with ****ing 6 granny flies on it (2 bullets each) and I proceed to get pelted to death while I try desperately to doge. Screen looks like this:
You die because the flies are all spread out and you have nowhere to dodge and your attack takes forever to charge and then you get pissed cause you realize you just died to ****ing FLIES after 2-shotting bosses.
**** you, Isaac. **** you.