Yesterday I played a really weird game.
After level 2 whenever I entered a shop it would play the mini-boss encounter them but no boss would be in the shop. It was just empty, so I couldn't buy anything for the rest of the game
Also, when I fought mom I was indestructible. I went down to my last half heart and after that stopped taking damage. Not sure exactly what my item setup was but it was weird. I remember I had Mitre and brimstone but that's about it.
Oh yeah, on top of that my brimstone charge up was slower than I've ever seen it before. I'm talking like 5 seconds to charge it up. I don't remember eating an unusual amount of negative effect pills, it was more like it just slowed down from level to level.
My meatboy carried me real hard though so i was able to kill mom's heart and find the box but then the game ended.