I think that's player dependent. I make it bigger against fish (create more dead money, and bigger pot if we want to value bet) and smaller against good players (to have as much room as poosible postflop).
I don't think anyone has a clear answer. My personal opinion is probably yes, it makes sense to go back to 3x. But I've seen small stakes players who said that's completely wrong and you should keep it 2.5x anyway.
But the truth is there's so many places where you can make a lot of profit. Mostly lines and situations where people bluff way too often/not at all, or call way too wide or never. The effort/reward ratio for trying to find optimal preflop betsizing is just not that good compared to these.
I thought about this a lot when facing fish who couldn't find the fold button. My BTN steal is always 2.5x, and I thought I was doing the right thing by stealing a lot and keeping SPR low in position. What I found was that most of these players would call one or two barrels way too often for me to be bluffing them or even thin value betting. In response, I tightened my range, upped my BTN steal to 3x, and increased my bet size on the flop and turn. Turns out most fish call a more inelastic range than I gave them credit for, and I just started value betting them to death.
The moral of that story is that if you have the luxury of having opponents that don't adjust, you can experiment without having to worry if they're noticing.
To answer your question more directly, no, I don't see why you should change your sizing just because you're deep. But being deep + knowing opponent's tendencies + having a set plan? Sure, why not.
he means that you cant really steal these guys blinds because they dont like folding. so you should be opening hands like K6s/Q7s and stuff so that when they call with their trashy 75o/63s or w/e, we have them dominated a lot postflop and can outplay them by cbetting decent boards where its hard for them to hit something and also by value betting them thinly and using position well to manage the pot to a size in which we desire with our relative hand strength.