Playing 5-handed online $0.05/$0.10, Hero has just joined the table and is playing the first hand out of the BB, so no reads or stats. Effective stack is $10 exactly.

Folds to V on the BTN, who raises to $0.50, SB folds, and Hero calls with KQ

Flop: 7JA

Hero checks, V bets $0.42 into a pot of $1.05, Hero calls.

Turn: 3

Hero checks, V bets $0.89 into a pot of $1.89, Hero check-raises to $3.02, V calls.

River: 2

Hero jams $6.06 into a pot of 7.93
????

So slightly worried about the larger sizing pre-flop, don't know if this is just what he does or a bet-sizing tell, I honestly considered folding. I don't 3-bet in fears of getting 4-bet because of the larger sizing, possibly could reconsider. On the flop, it is a small bet and I have a gutshot+backdoor nut flush, so floating seems like a good play, however I could possibly pick some better spots to float with this hand. On the turn, his bets are so weak it seems like he will check back river, which might mean he would fold if I needed to bluff. I raise to size up the river jam. River is a total brick, and this bluff needs to get though a lot of the time to be profitable, what do you guys think about a player with no reads? Trying to fold out a weak two pair or AK/AQ type hand.

You're right to be worried about the larger preflop sizing. Occasionally, it'll be a fish just doing whatever, but I find that villains who have some idea most often do this with a particularly tight range.

Usually I'd peel the flop facing a normal preflop sizing, but not really thrilled to do so here. Never going for a bluff raise though, I think it could be possible that we have no fold equity whatsoever.

Ignoring exotic sizing I think I'd just call turn to try and show down and if he bets look to pull the ol' blocker CRAI OTR.