My most frequent one so far is "So will I be seeing you on TV?" I just politely state that I only play online, so probably not.
If you guys think poker's tough, try telling people you're a competitive Scrabble player. Tournament Scrabble is about 50 times as different from living room Scrabble as serious poker is from a penny ante home game.
"Oh, I could never be good at Scrabble--I'm such a bad speller."
"That's okay. Many of the top players are Thais who don't even speak English."
I'm always afraid to meet someone who'll be like "My dad lost his life savings playing online poker."
"There's this great book called Small Stakes Holdem--I'll lend him my copy."