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Because they're physically and mentally destructive in general even without the prohibitionist idiocy.
This is a pretty horrendous sweeping generalisation to make. How is marijuana physically destructive? What about LSD? Both of these have no long term adverse physical effects. In terms of being "physically destructive", your Big Mac is going to be far far more -EV for your body than the vast majority of drugs. Of course, if you're a heroine addict, this is a different story. Of course, if you're overdosing on MDMA, this is a different story. If you're stupid enough to do that though, perhaps the world is now a better place without you.
Now in terms of mentally destructive, certainly a benzo addiction is going to be very -EV. In terms of drugs generally, however, they don't come close in comparison to mentally malevolent (and legal) things such as gambling addictions, or dealing with depression, etc. In fact, many would say the benefits of taking psycs (LSD, psilocybin, DMT, etc) are very very +EV for you mentally. No adverse effects and the ability to better perspectivise as well as expand your own consciousness.
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Why wouldn't we want fewer addicts and fewer sicker, dumber people?
Certainly, we would love fewer addicts. Addiction is everywhere, however. Gambling, food, sex, etc. Most drug users are responsible, just like most gamblers are. You're conflating all drug users with addicts, which simply is not correct.
"fewer sicker [people]" Well, the only "sick" drug users are the ones with dependencies which, as I said, is only a very small number. Proper education (which would accompany legalisation) would take care of this to a large degree also.
"fewer dumber [people]" Obviously this is a red herring and has nothing to do with drug use. To think that drugs users are inherently dumb or will be cured of their dumbness through abstinence is naive. Many of the most intelligent people in the world have been known to use psycs/other substances regularly.
In all honesty, it just comes across as if you have some sort of personal vendetta against drug use. It's the classic rightist case of "drugs are bad"; "drug users are deadbeats", etc etc without actually putting any thought into it. You think drugs are bad because this is what you were told. You inherited this ideology and have failed to question it before adopting it as your own.
Apologies for typos etc, spell checker is broken currently.