Hi all, i'm a newbie in PLO, so may be my question is trivial or discussed earlyier (i tried to search but find nothing)

As it seems to me - almost all hands - maybe except top non-A pockets - are better in one-to-one postflop. Better for bluff, better for bluff-catching, better for made hands and most times better for SD because of possible redraws, backdoor FDs and so on. Hands with top-cards - AK, AKQ, AKJ are much better in one-to-one then in multiway pot. Hands like 789J are also good in HU post-flop when u hit x8J for example. And its marginal FDs have much more equity in HU.

So the question is - am i right thinking that i should avoid multiway pot as much as i can? 3betting all hands i plan to play (except set-mining QQ/KK) IP (at least when no raise-call action before me), and often 3bet from blinds if i saw limp-limp-bet action before me and plan to play my AKT4ss for example?

You should not avoid multiway pots.

You should be in profitable spots. It takes different skills to play multiway.

HUPLO might be more suitable for you as a game if you feel this.