If that is a fold at 200BB then I do not think it is a call pre! How are you making money if it feels sick and there is a higher card to the flopped 1 in 8 set 70% of the time.
Sets in PLO are not that strong you are often flipping on the flop or drawing to Quadies.
Hard to make money OP minimising losses is not terrible. 20 Cents I call. 25 Cent I think it is close. 30 Cent I am snap folding.
Yes huge draw or set. Think I pay it off but a huge draw often plays better to flat so most unbalanced (bad) players lean towards a set, in my view. But think you have to call given pre since what are you hoping for top set this will only occur less than 0.125*0.3= less than 4% of the time. Will you get enough action when you do?
Fold pre, Fold/Call do not hate the raise but raise folding a hand this strong is strategically insane.
Edit -
Overall: Cooler maybe bit loose pre stack size is also super duper awks you want a hand that is super nutty with 200BB esp
Definitly a better defend at 100BB