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How to find weed in a new town How to find weed in a new town

07-19-2010 , 02:33 PM
Quote:
Originally Posted by LeapFrog
Also, it is illegal in some states now and its metabolites may cause cancer. I don't know how much of a risk though, it could just be on par with smoking.
metabolites for red meat may cause cancer. at 30-40mg per dose, cancer is hardly a concern. tobacco is way worse.
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07-19-2010 , 02:40 PM
Quote:
Originally Posted by sylar
metabolites for red meat may cause cancer. at 30-40mg per dose, cancer is hardly a concern. tobacco is way worse.
I have to nit it up here
http://www.erowid.org/experiences/exp.php?ID=76486
Quote:
Vaporised 3-5 mg 018 through oil pipe. This was a virgin experience (no other drugs) and we definitely felt the effects of the chemical this time. Very pleasantly surprised.
people shouldn't eat red meat either Anyway, like I said, I don't know of how much of an actual risk jwh-018 (and other synthetics) present
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07-19-2010 , 02:44 PM
Quote:
Originally Posted by LeapFrog
I have to nit it up here
http://www.erowid.org/experiences/exp.php?ID=76486

people shouldn't eat red meat either Anyway, like I said, I don't know of how much of an actual risk jwh-018 (and other synthetics) present
Quote:
Day 1 - Saturday
Marijuana had been smoked previously during the day, and directly before first ingestion of the 018, so the first day was difficult to differentiate the marijuana from the 018. No mg scale around, we very carefully shaved off 3-5 mg of product (when not condensed into a 'rock', the product looks light yellow) and inserted it into an indirect heating/oil pipe (bubble pipe). Keeping the flame under the product, it melted and began boiling/smoking. Inhaled all subsequent vapors in one breath. It has a distinct flavor reminiscent of N,N,DMT.
??? very unreliable. most accounts i've seen for mixing jwh with everclear, effects are felt at 30-40mg consumption. this is anectodal though. i have no reference point other than some blog, even though toxicology is referenced in it.

Quote:
GreenScreen HC Genotoxicity Assay

This assay looks at how much a drug will interfere with our DNA. Typically, anything that damages DNA is bad news, being potentially carcinogenic, making the rationale behind this test glaringly obvious. This test was also performed in the presence of a fraction taken from liver cells, which will break down the drug. This not only checks if the drug will damage DNA, but also its breakdown products.

Results: JWH-018 does not damage DNA, so shouldn’t give you cancer.
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07-19-2010 , 02:52 PM
Quote:
Originally Posted by sylar
??? very unreliable. most accounts i've seen for mixing jwh with everclear, effects are felt at 30-40mg consumption.
According to the accounts I have read, 5-10 seemed to be the norm. But yeah, who knows for sure. I certainly wouldn't try 30 off the bat.

edit: wiki says
Quote:
The usual dosage for individual consumption (orally) varies greatly per individual but is typically between 3 and 20 milligrams.[citation needed] When smoked (as opposed to consumed orally) the amount needed may be lower, however the observed effects have a shorter duration.
wiki always right
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07-19-2010 , 02:58 PM
Quote:
Originally Posted by sylar
i have no reference point other than some blog, even though toxicology is referenced in it.
http://www.bluelight.ru/vb/showthread.php?t=474536
Quote:
New evidence for cancerogenic metabolites from JWH-018
It was speculated numerous times if JWH-018 and its close congeners (in particular 015 and 073) could act as cancerogenics. See e.g. this thread (JWH-018-related; very lenghty) and this thread (JWH-073-related).

To repeat the mentioned arguments in short:
For JWH-015 it was shown (using fractions of liver microsomes, to emulate the metabolic environment of the rat liver) that certain pathways of the compounds metabolism included epoxide-intermediates, which are quite infamous for causing cancer, similar to benzen's metabolism. The respective reference is Analytical and Bioanalytical Chemistry 2006, 386(5), p.1345.
Because in particular JWH-018 is structurally very close related to JWH-015, it was assumed by some folks (incl. me) that JWH-018, a very popular 'legal' cannabinoid, is potentially harmful.
Of course, one has to add to the discussion the numerous by-products of the synthesis, which were not removed lege artis in the first batches (...which were orange coloured), but this should not be part of this thread and is another topic.

This discussion was, of course, quite speculative due to the lack of appropriate metabolism studies with JWH-018 and lots of people disagreed with the cancerogenity-proposal.


Now I have found novel evidence that the doubts over JHW-018's benignity were justified. (Thx to Vecktor, who posted the resp. link elsewhere, where I now found the info). I quote:

Quote:
Results: The parent compounds JWH-018 and CP47 could be found in the urine extracts. For JWH-018, the N-dealkyl metabolite could be detected as well as the hydroxylated metabolite. The highest signals could be observed for the hydroxylated N-dealkyl metabolites. Hydroxylation took place in the side chain and in both aromatic systems, the naphthalene and the indol part, which could be shown by mass shift of the corresponding fragments and by MS3 experiments. For CP47, several hydroxylated metabolites could be identified. Aliphatic hydroxyl groups could be differentiated from aromatic hydroxyl groups by different fragmentation patterns (loss of water/acetic acid for aliphatic hydroxyl groups).
naphthalene ring imo
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07-19-2010 , 03:05 PM
pretty sure that's a rat study
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07-19-2010 , 03:20 PM
Quote:
Originally Posted by sylar
pretty sure that's a rat study
Yes, wistar rats. I'm sure the Chinese prisoner study will be conducted soon.

look, I'm not an organic chemist, a physician, etc -- nor a student of these disciplines. If you have a point to make, please make it clear for a layperson.
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07-19-2010 , 03:34 PM
btw, sorry, i totally misread someone's comment on that blog. it appears the everclear method makes 1-1.5 mg/mL, with 3-4 mL doses. so yes, actual consumption is between 3-6 mg.
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07-19-2010 , 03:36 PM
JWH is inferior to the real stuff - doesn't last as long, weaker effects, and definitely a more anxious experience. On the other hand it's cheaper and doesn't show up on drug tests. I don't plan on touching it again, esp. with this new info that it has carcinogenic metabolites... no thanks. Are there any cannibinoid synthetics without carbon rings?
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07-19-2010 , 03:38 PM
Quote:
Originally Posted by sylar
btw, sorry, i totally misread someone's comment on that blog. it appears the everclear method makes 1-1.5 mg/mL, with 3-4 mL doses. so yes, actual consumption is between 3-6 mg.
its cool. Can you explain the rat thing though? I mean obviously there are differences, but given that so many studies are done on rats, I presume that you can draw some conclusions as to what would happen in humans.
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07-19-2010 , 03:42 PM
Quote:
Originally Posted by AKSpartan
JWH is inferior to the real stuff - doesn't last as long, weaker effects, and definitely a more anxious experience. On the other hand it's cheaper and doesn't show up on drug tests. I don't plan on touching it again, esp. with this new info that it has carcinogenic metabolites... no thanks. Are there any cannibinoid synthetics without carbon rings?
anyone?
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07-19-2010 , 03:45 PM
Quote:
Originally Posted by SELFMADE
anyone?
I recall that jwh-200 (210? or one of them) may not have the naphthalene ring. I think I posted about it in the synthetic thead in OOT, wherever that may be.

I decided not to go with the synthetics months ago and promptly began the forgetting process.
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07-19-2010 , 03:51 PM
Quote:
Originally Posted by LeapFrog
its cool. Can you explain the rat thing though? I mean obviously there are differences, but given that so many studies are done on rats, I presume that you can draw some conclusions as to what would happen in humans.
i am not a chemist nor a nutritionist, but most articles that i've read that compare human studies to rat studies indicate that rat studies to be taken with a grain of salt. there are enough differences in human and rat metabolism that conclusions can't be drawn, at least not without full rat-human comparison studies on related compounds.
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07-19-2010 , 03:52 PM
Quote:
Originally Posted by SELFMADE
anyone?
pretty much every report on the webz says it's not as good as the real thing. take it as best available evidence.
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07-19-2010 , 03:52 PM
It's been like a while now, have you gotten high yet?
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07-19-2010 , 09:26 PM
no luck. at these moments in life, i wish i had made more friends.
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07-19-2010 , 10:02 PM
wow seriously where i work people ask me a couple times a day if i want to smoke a bowl
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07-19-2010 , 11:32 PM
where you work you around chicago?
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07-20-2010 , 12:59 PM
Quote:
Originally Posted by AKSpartan
JWH is inferior to the real stuff - doesn't last as long, weaker effects, and definitely a more anxious experience. On the other hand it's cheaper and doesn't show up on drug tests. I don't plan on touching it again, esp. with this new info that it has carcinogenic metabolites... no thanks. Are there any cannibinoid synthetics without carbon rings?

I beg to differ, the reports that it has carcinogenic metabolites is just propaganda put out there to scare people off. In reality it is most likely much less carcinogenic than marijuana.

www.jwh018free.com is one of my sites.

Guys, for those of you that don't believe this stuff is the real deal, or just think the site is BS, email me through the website and I will send you some for free. Just mention your 2+2 handle. I am legit, and so is the product.
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07-20-2010 , 01:02 PM
Quote:
Originally Posted by trikflow77
I beg to differ, the reports that it has carcinogenic metabolites is just propaganda put out there to scare people off. In reality it is most likely much less carcinogenic than marijuana.

www.jwh018free.com is one of my sites.

Guys, for those of you that don't believe this stuff is the real deal, or just think the site is BS, email me through the website and I will send you some for free. Just mention your 2+2 handle. I am legit, and so is the product.

we know "the stuff" is the "real deal". where is your source saying that it isn't harmful?
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07-20-2010 , 01:27 PM
Quote:
Originally Posted by SELFMADE
no luck. at these moments in life, i wish i had made more friends.
Don't worry, 95% of OOT feels the same way.
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07-20-2010 , 02:19 PM
95 is a bit conservative.
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07-20-2010 , 03:37 PM
Quote:
Originally Posted by SELFMADE
no luck. at these moments in life, i wish i had made more friends.
So you have a pipe and a bong but no dro?

Don't you drive a taxi? You probably transport a few ounces daily.

Bickle could hook a fare up in two minutes. Take your job more seriously.
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07-20-2010 , 03:59 PM
I quit taxi job few weeks ago. Yes I bought a pipe from a head shop and my bong should be arriving any minute now. Don't know what "dro" is.
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07-20-2010 , 04:09 PM
Quote:
Originally Posted by SELFMADE
I quit taxi job few weeks ago. Yes I bought a pipe from a head shop and my bong should be arriving any minute now. Don't know what "dro" is.
LOL just give up now. Not on the weed thingy, but this whole gimmick account. Too many holes, and your latest thread is a gem.
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