It's also my understanding that the little guy stands to make almost nothing in the production of pot for consumption once this goes legal. For instance in Canada, prostitution is on the brink of going full legal. Literally the day after that battle was won, big money starts announcing super brothels.
Where big money can be made, big industry follows. Super farms, lowest production costs and labour, distribution channels, and so on.
Now all that being said, I think a brilliant mind could make money in the equivalent of the "whole foods" or "natural pantry" type spaces. Niches will be carved out in this industry, above and beyond the typical pounds of weeds of all strains. The tough part is that I think you need to be investing and developing your idea now, and creating your brand now. That's not easy in Canada for example (where I live). My friend and I have a few niche ideas, I'm not really at liberty to discuss them. But that's where I think the little guy can score. That and insider trading on who might be the big players to move into the weed space. I suppose there's probably also good upside in the accessory space. In Canada a site like
http://vaporizers.ca/ just could never handle the demand that would follow legalization. So a bunch of people will fight over drop shipping those goodies.