A new Zachtronics game called Shenzhen IO is out on Steam. It looks to be a more involved take on TIS 100. You build simple circuits using programmable controllers (and a few other devices) and various inputs and outputs that feed in to them, and program the controllers with a fairly similar assembly language to turn the provided inputs into the required outputs. It has more of a story to it than TIS, a bit like Spacechem, and probably the best looking Zachtronics game outside of Infinifactory. I have about two hours in to it and love it.