If there isn't enough interest in a tradition FF league, a suicide pool may be a good way to go since it's much easier to understand.
Basically you have to pick a one team to win each week. The catch is, you cannot pick the same team twice. Once you pick incorrectly, you're out of the pool (unless we were to allow rebuys, which I have seen but is usually only done within the first two weeks if at all). Last person standing wins.
Obviously you end up having to try to pick some weaker teams (for example, picking a winner in the Browns/Bengals matchup in Week 1 even if you are sure that a very good team like the Pats or the Colts are going to crush their match-up that week) so that if you go deep you can have a couple of juggernauts standing at the end of the year (in case two or more people make it all the way to the end and have to keep picking into the playoffs).
The other option would be a week by week traditional "pick the winners" game where you put in $5 a week, everyone picks the winners of all the match-ups, and the whoever picks the most winners that week wins all da dough (with the traditional tiebreaker being picking the point total/score for the Monday night game).
Any of these would be a good way for people to get involved if they find drafting a traditional FF team to be a little daunting.
I'd be happy with any league.