Pokerstove only claims to "know" things all in preflop (or whichever street you enter). Any reading of the results for a 4 street game that doesn't involve deeper analysis is user error, not false claims by the tool.
This probably comes from my being old-school, but I always remember Mason and maybe Ray Zee talking about "good control of the table" or concepts like that when looking at spots. The idea being where you just have such a good idea of what your opponents are up to and them being very straightforward, you never really get that lost in a hand. Maybe the next step is being a world class talker where you can wheedle a bonus call or fold from a single villain? So let's say you're Babar or someone like him and have many millions of online hands and thousands of hours of live poker, and you're never losing extra vs the villains in a pot (they're transparent) and you're going to make the absolute max, as much as possible OOP. You have good control of the situation, maybe you can profit in these spots?
At some point, clearly the price is right. UTG opens, there are two posters with dead SBs, 7 people take 2 to the face, and you're getting 18:1, you probably can't turn down the overlay. We're only debating the price. If 18 isn't enough, put a $100 splash pot in an 8/16 and you have 12 bonus small bets in the middle. It isn't "hand X is never a VP$IP", it is just about whether or not the price is right.