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Are there software tools (or other tools) available that will help in this? If so, where would you start in terms of which tools to use to start down this rabbit hole? Basically, I am trying to figure out what can help me construct good "rule of thumb" ranges for opening in EP, MP, LP, etc. Obviously, these will be very fluid based on opponents, table dynamics, perceived images, blah blah blah. But I feel like I need to start somewhere.
If your looking for some kind of baseline, maybe start with online ranges? Won't really apply to live play but their probably more fundamentally correct.
Live play is just too wide for general rules of thumb. Just the deviations in stack sizes alone create a very large number of combinations, not to mention the players themselves.
I think your approach should instead focus on why your range should be changing, then you'll be able to adapt it for any situation.